木犀草素拮抗糖尿病腎病分子機制研究進展

1．昆明醫(yī)科大學藥學院暨云南省天然藥物藥理重點實驗室，云南昆明650500；2．昆明醫(yī)科大學第一附屬醫(yī)院，云南昆明650000

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【中圖分類號】R966 【文獻標志碼】A 【文章編號】1007－8517（2025）11－0076-07

DOI：10.3969/j. issn.1007-8517.2025.11. zgmzmjyyzz202511016

Research Progress of Luteolin in the Treatment of Diabetic Nephropathy

YU Xiaoze1HUANG Rong1WANG Xuewei2SHI Yunke2MA Yiming2 ZHANG Ling1LUO Min1 CAI Hongyan2 LI Yan2 YANG Weimin1 * 1.School of Pharmacy，Kunming Medical University and Yunnan Provincial Key Laboratory of Natural Drug Pharmacology，Kunming 65050o，China; 2.The First Afiliated Hospital of Kunming Medical University，Kunming 65OoOo，China

Abstract：Diabetic nephropathyisaserious threatto human health，primarilycharacterizedbyabnormal renalhemodynamics， includinghighglomerularfltratioandpefusionstates.Asthconditionprogresses，teaccumulationofadvancedglycationedproductsgraduallydestroysrenalfiltrationfunction，leadingtoincreasedurinaryalbuminandrenalfailure，amongothersevereconsequences.Thepathogenesisofdiabeticnephropathyiscomplexandinvolvesdisordersinglucosemetabolism，vascular/blodflow，secretionof inflammatorycytokines，xidativestress，andmore.Luteolinisfavooidompoundextractedfromthespecialyplants， suchaslampflowerfoundinYunnanIttargetsthemolecularmechanismsofdiabeticnephropathyndexertsitstherapeuticeffects througharious targetpathways.Luteoliplaysacrucialoleinimprovingmicrociclation，protectingthecardiovascularsystemnti -inflammation，andantioxidantactions.Thisarticleaimstoreviewthemolecularmechanismsofdiabeticnephropathyandthere search progress on the molecular mechanisms of luteolin in treating diabetic nephropathy.

Key words：Diabetic Nephropathy；Luteolin；Target Points；Signal Pathway

糖尿?。╠iabetesmellitus，DM）是一類以高血糖為主要病理特征的代謝疾病。（剩余17910字）