基于藥效及正交設(shè)計(jì)優(yōu)選金喉顆粒的提取工藝

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【中圖分類號(hào)】R284.2 【文獻(xiàn)標(biāo)志碼】A 【文章編號(hào)】1007－8517（2025）11－0060-05

DOI：10.3969/j.issn.1007-8517.2025.11. zgmzmjyyzz202511013

Optimization of Extraction Process of Jinhou Granules Based on Pharmacolodynamics and Orthogonal Design

Honghui JIANG Tao* ZENG Chen SU RuihuiCHEN LisiCHEN Xiaojian PENG HongyingWANG Chuany Guangzhou Baiyunshan Jingxiutang Pharmaceutical Company Limited，Guangzhou 51O13O，China

Abstract：Objective Tooptimize theoptimalextraction process ofJinhou granules（JHG）．Methods Basedonthescreeningresultsofpharmacodynamicexperiments，anorthogonalexperimentwasdopted，withtecomprehensivesoreofangiferintraseate anddrycreamieldasevaluationindicators，ndthefactorsofwateradition，extractiontime，ndextractionfrequencyaseaation factors，tooptiizeteextractionprocessofJinhougraulesandonductprocessvalidatioResultsTeanti-amatoryctiityf thewaterextractionprocessofJinhougranulesissuperiortothatoflcoholextractionandwaterextractionandalcoholprcipiation processes.Theoptialextractionprocessistoad10timestheamountof waterandrefuxtwice，achtimefor1.5hour.Thevalidation test results showed that the average transfer rate of mangiferin was 72.30% （ RSD=2.0%，n=3， ，and the dry cream yield was （204 19.20% （RSD=3.5%， n=3 ）.Conclusion The optimized extraction processfor Jinhou granules is stable and feasible with good repeatability，which can provide experimental reference for subsequent production process research.

KeyWords：Jinhou Granules；Orthogonal Design；Extraction Process；Anti-inflammatory effct；Mangiferin

金喉顆粒處方源于中醫(yī)藥大學(xué)趙思競(jìng)教授臨床經(jīng)驗(yàn)方，方中由小金牛草和崗梅兩味中藥材組成，該品種是由的獨(dú)家品種金喉散經(jīng)工藝和劑型改革而來。（剩余6769字）