冬瓜皮水提物抗氧化活性及降尿酸作用研究

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Study on the Antioxidant Activity and Uric Acid-Lowering EffectofWaxGourdPeel WaterExtract

TONG Rong， QIN Si* （HunanAgriculturalUniversity，Changsha41O128，China）

Abstract： Objective： To study the antioxidant activity and uric acid-lowering effect of wax gourd peel water extract.Method： The scavenging ability of wax gourd peel water extract on DPPH free radicals and ABTs+ free radicals and the inhibitory ability on Xanthine oxidase （XOD）activity were evaluated by in vitro experiments.The uric acid-lowering effect of wax gourd peel water extract was evaluated by establishing a hyperuricemia HepG2 cell model. Result： The half-inhibitory concentrations of wax gourd peel water extract on DPPH，ABTS*，and XOD were 1.04， 0.96， and 0.80mg?mL-1 ，respectively. In hyperuricemia HepG2 cells， wax gourd peel water extract could effectively reduce XOD activity （  p  < 0 . 0 1  ）. Conclusion： Wax gourd peel water extract has antioxidant and uric acidlowering abilities，which providesan important theoretical basis for the development of functional foods and the prevention of chronic diseases.

Keywords： wax gourd peel; hyperuricemia; antioxidant; uric acid-lowering

高尿酸血癥（Hyperuricemia，HUA）是臨床上常見的慢性代謝性疾病，其發(fā)病機制主要涉及嘌呤代謝紊亂與尿酸排泄功能異常，進而引發(fā)尿酸生成過多或排泄不足，從而表現(xiàn)出血清尿酸值偏高[1]。（剩余4932字）