睡眠障礙患者頸動(dòng)脈斑塊進(jìn)展的超聲動(dòng)態(tài)監(jiān)測(cè)

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AbstractObjective：Toinvestigate therelationshipbetweensleepdisorders，especiallyObstructive SleepApnea（OSA）andcarotidplaqueprogresionandtoevauateitspotentialimpactofsleepdisordersoatheroslerosis.Methods：Atotalofpatints withsleepdisordersadmitedinthehospitalfromJune2O toJune2O24 wereincludedasthestudyobjects.Theyweredivided into an OSA group（ n=70 ） and a non-OSA group（ n=30 ） according to whether they were OSA patients.All patients underwent polysomnography（PSG）andthecarotid Dopplerultrasound scan beforetheenrollment andhad a6-month folowup.Therelationshipbetwensleedisordersandcarotid plaque progressionwasexploredbyanalyzingsleepmonitoringidicators，suchasapnea index（AHI），lowestbloodoxygenaturation，ndrsultsofcarotidulrasound，incudingplaquemorpholog，ie，tia-dia thickness（IMT），peak systolic velocity（PSV），etc.Results ：The rate of carotid plaque area increase in OSA group（ 60.00% ）was significantly higher than that in non-OSA group 30.00% ） within 6 months and IMT and PSV of the observation group increased significantly. Multivariate regression analysis showed that the IMT increased by 0.15mm2 and PSV increased by 0.18 cm/s for every 1 time/h increase in AHI. For every 1% decrease in the lowest oxygen saturation，the IMT increased by O.1O mm2. Conclusion：Sleepdisorders，especiallyOSA，arecloselyassociated withcarotidplaqueprogresion，andtherateofplaqueprogesin OSA patients issignificantlyhigherthanthatinnon-OSApatients.AHIandlowest oxygensaturationareimportantpredictors for carotid plaque progression.

KeywordsSleep disorders; Obstructive sleep apnea; Carotid artery plaque； Ultrasonic dynamic monitoring; Blood oxygen；Apnea index；lowest blood oxygen saturation；Arteriosclerosis

中圖分類(lèi)號(hào)：R338.63；R56 文獻(xiàn)標(biāo)識(shí)碼：A doi：10.3969/j. issn.2095-7130.2025.04.020

睡眠障礙，尤其是阻塞性睡眠呼吸暫停（Ob-structiveSleepApnea，OSA），已被認(rèn)為與心腦血管疾病的發(fā)生密切相關(guān)[1]。（剩余3873字）