HIV感染者睡眠障礙的多維因素分析

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AbstractObjective：To explorethemultidimensionalfactorsofsleepdisordersinHIV-infectedindividuals.Methods：Atotalof 86HIVinfectedindividualswereincludedfrom Marchto November2O24.Demographicdataanddisease-relatedinformationof the enroled patients werecollctedandtheirsleepqualitywas evaluatedbythePitsburgh SleepQualityIndex（PSQI）.Logisticregresion wasappiedtoanalyzefactorsafectingsleedisorders inHIV-infected individuals.Results：Among the86HV-infected patients enrolled，a total of 48 patients had sleep disorders，with an incidence rate of 55.81% . The analysis chi-square test showed thattherewasnoobviouscorelationbetweentheoccurrenceof sleepdisordersandfactorssuchasgender，age，transmision route，marriage，education background，and occupation（ P>0.05 ）. The results of monofactor analysis showed that the occurrence of sleep disorders in HIV-infected individuals was related to anxiety，depression，treatment duration， CD4+ T lymphocyte count，viral load，and treatment protocol（ P<0.05 ），and not related to smoking or alcohol consumption（ P>0.05， ）. Logistic regression analysis showed that anxiety（ OR=3.356 95% CI 1.465 to 6. 782），depression（OR=2. 762， 95% CI 1.325 to 5.205），treatment duration（OR=1. 932， 95% CI 1.234 to 3. 051）， CD4+ T lymphocyte count（OR =2.192，95% CI 1.356 to 5.008），and treatment protocol（ OR=1.986，95% CI 1.265 to 4.324）were the main factors influencing sleep disorders in HIV-infected individuals （ OR>1，P<0.05 ）. Conclusion：Sleep disorders in HIV-infected individuals are influenced by various factors including anxiety， depression，treatment duration， CD4+T lymphocyte count，and treatment protocol. It is crucial to focus on high-risk factors and provide targeted interventions to improve HIV patients'sleep quality.

KeywordsHIV infection;Sleep disorders；Sleep quality；Multivariate analysis中圖分類號：R593.3;R256.23 文獻(xiàn)標(biāo)識碼：A doi：10.3969/j. issn. 2095-7130.2025.04.009

人類免疫缺陷病毒（Human ImmunodeficiencyVirus，HIV）主要攻擊人體免疫系統(tǒng)中最重要的CD4+T 淋巴細(xì)胞，造成免疫系統(tǒng)損害、相關(guān)免疫功能逐步喪失，從而使人體易于感染各種疾病，同時(shí)導(dǎo)致惡性腫瘤發(fā)生，最終發(fā)展成為艾滋病[1]。（剩余5279字）