重復(fù)經(jīng)顱磁刺激聯(lián)合奧氮平治療在精神分裂伴失眠患者中的應(yīng)用及對睡眠質(zhì)量的影響

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AbstractObjective：Toanalyzetheefectsofrepetitivetranscranialstimulatiocombinedwitholanzapineothesleepqualityof patients withschizophreniaand insomnia.Methods：Atotalof ninetypatientswith schizophreniaandinsomniaadmitted to the FifthPeople'sHospitalof Zibo CityfromJanuary 2O23 to December2024were selectedastheresearchsubjects.Theywererandomly divided into a control group（ n=43 ） and an observation group（ n=47 ）by random number table. The control group was treatedwitholanzapine，whiletheobservationgroupwastreatedwithrepetitivetranscranialmagneticstimulationcombinedwith olanzapine.The Brief PsychiatricRatingScale（BPRS）wasused toevaluatethe degreeofschizophreniainbothgroupsof patients.The Pitsburgh SleepQualityIndex（PSQI）wasusedtoevaluatethechangesinsleepqualitybeforeandafterintervention， andthe incidenceofadversereactions wascomparedbetweenthetwogroups.Results：Aftertheintervention，theBPRSscoreand PSQI scoreoftheobservation groupweresignificantlylowerthan thoseof thecontrol group，andthediference betweenthe two groups was statistically significant（ P<0.05 ）； The incidence of adverse reactions in the observation group was significantly lower than that in the control group and the difference between the two groups showed no statistically significant（ P>0.05 ） . Conclusion：Thecombinationofolanzapineandrepetitivetranscranial magneticstimulationhas significanttherapeutic efectsonpatients with schizophreniaand insomia.Itisnotonlybeneficialforimprovingpatients‘mental symptoms，butalsopromotesthesleep qualtiy back to normal. It is worth promoting and applying in clinical practice.

KeywordsSchizophrenia； Insomnia；Transcranial magnetic stimulation；Repetition； Olanzapine；Mental symptoms；Sleepquality； Adverse event

中圖分類號：R749.3;R338.63 文獻標(biāo)識碼：A doi：10.3969/j.issn.2095-7130.2025.04.001

精神分裂癥屬于復(fù)雜的慢性精神障礙，全球患病率約為 1% ，其核心癥狀包括陽性、陰性癥狀及認(rèn)知損害。（剩余6044字）