賴氨酰氧化酶家族在腫瘤發(fā)生發(fā)展中的復(fù)雜作用

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關(guān)鍵詞：賴氨酰氧化酶；腫瘤；復(fù)雜作用

中圖分類號：R34；R730.23文獻標志碼：A 文章編號：1001-5779（2025）05-0476-09

DOI：10.3969/j.issn.1001-5779.2025.05.012

Abstract：The lysyl oxidase （LOX）familycomprises secreted copper-dependent amine oxidases that plays a crucial role infacilitatingthecovalencross-lnkingofcollgenandelastin，therebypromotingtheformationofacross-linkingnetwork withinthe extracelular matrix（ECM）and maintaining its normal structure and function.Studies have suggested thatthe proteins belonging to the LOX familyare involved in shaping the tumor microenvironment prior to metastasis through various signaling pathways，exerting eitherpromoting orinhibiting effectsontheproliferation，invasion，andmigrationof tumor cells，which underscores their significantrole in theonsetand progression of various tumors.This makes the LOX familyapotentialtargetfor tumor diagnosisand treatment.Thisarticleaims toreviewthe expressonand underlying mechanismsoftheLOX familyintumors，enhancing ourunderstandingof thecomplexrolesoftheLOXfamilyin tumor progression and providing a reference for tumor monitoring and treatment.

KeyWords：Lysyl oxidase;Tumor；Complexroles

賴氨酰氧化酶（Lysyloxidase，LOX）是由細胞分泌的、作用于細胞外基質(zhì)（Extracellularmatrix，ECM）膠原和彈性蛋白的賴氨酸殘基從而產(chǎn)生分子交聯(lián)的一種胺氧化酶。（剩余17904字）