抗氧化基因1與神經(jīng)退行性疾病：從分子機(jī)制到靶向藥物研究

打開文本圖片集

中圖分類號(hào)：Q754 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：1001-5779（2025）05-0424-05

DOI：10.3969/j. issn. 1001-5779.2025.05.002

Abstract：Oxidationresistance gene1（OXR1），asan evolutionarilyconserved endogenousantioxidant defense system coreregulator，playsakeyroleinmaintainingcellularredoxhomeostasis.Studies haveshown that OXR1canbuildamultilevelantioxidantdefensenetwork toprotectcelsfromoxidativedamagebyregulatingantioxidant pathways，maintaining mitochondrial function，and stabilizing thereverse transport complex.Theabnormal expresson ofOXR1is closely related totheoccurrenceanddevelopmentofoxidativestress-relateddiseases （suchasneurodegenerativediseases，cardiovasculardiseases and malignant tumors），butthe mechanism of action is complex.This article reviews the structure， function，role，andpharmacologicalresearchofOXR1，providingatheoreticalbasis forunderstandingitsinvolvementin neurodegenerative diseases and the development of OXR1-targeting drugs.

Key Words： Oxidation resistance gene 1； Neurodegenerative diseases；Oxidative stress；Reactive oxygen species

氧化損傷是機(jī)體在生理或病理?xiàng)l件下，活性氧（Reactiveoxygenspecies，ROS）過度累積引發(fā)的分子級(jí)聯(lián)反應(yīng)，通過破壞脂質(zhì)、蛋白質(zhì)及核酸等生物大分子，誘發(fā)細(xì)胞功能障礙甚至死亡[1。（剩余10718字）