《血液儲存標準》對冷沉淀和新鮮冰凍血漿解凍后儲存條件修改的研究

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中圖分類號：R331.1 文獻標識碼：A

Abstract Objective To investigate thechanges in cryoprecipitate and fresh frozen plasma （FFP）after thawing due to modifiedstorageconditionsandtovalidatetherationalityof therevisions madetotheBloodStorageStandard.MethodsAtotalof 48 bags each ofcryoprecipitate andFFPpreparedfromOctober 2023 to August 2024at theNanjingRed Cross Blood Center wererandomlyselectedAftercomplete thawing，cryoprecipitate wasstoredunderfourconditions：4Cfor6hours，4Cfor24hours，24C for 6 hours，and 24°C for 24 hours. The changes in fibrinogen（ Fbg? ，coagulation factor VIII （FVIl），coagulation factor V（FV）， andcoagulationfactorII（FII）contentincryoprecipitateunderdiffrentconditionswerecompared.Aftercompletethawing，F(xiàn)FP was stored at 4°C for 24 hours and 4°C for l20 hours. The changes in total protein （TP），F(xiàn)bg，F(xiàn)VIl，，F(xiàn)V，and FII content were compared.ResultsAfter thawing，cryoprecipitate was stored under the four conditions. Compared with the initial F M content， the F M content decreased under all four conditions. The differences in F M content between the conditions of 4°C for 6 hours， 4°C for 24 hours，and 24° C for 24 hours and the original test results were statistically significant （ P<0.05 ）. After thawing， FFP was stored at 4°C for 24 hours and 4°C for l20 hours.There were no statistically significant differences in TP and Fbg content compared with O hours after thawing （ P>0.05 ）. The content of FVIll，F(xiàn)V，and FII decreased，and the differences were statistically significant （ P （20 <0.05 ）.ConclusionAfter the revision of the Blood Storage Standard（ ：WS399-2023∣ ，cryoprecipitate demonstrates better clinical efficacy，and FFP can be better utilized in clinical treatment while reducing waste.

Key words Blood Storage Standard;Cryoprecipitate;Fresh Frozen Plasma;Blood Quality; Blood Safety First-authorsaddress Nanjing Red Cross Blood Center，Nanjing，Jiangsu，2looO3，China

冷沉淀是由全血分離出的新鮮冰凍血漿（約 200mL 制備而成的白色絮狀物。（剩余7934字）