白細(xì)胞濾除技術(shù)在臨床輸血中的實踐與應(yīng)用專家共識

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中圖分類號：R331.1 文獻(xiàn)標(biāo)識碼：A

Abstract Reducing the input of white blood cells is crucial for preventing adverse reactions to blood transfusion. The useof the Leukocyte DepletionFilter（LDF）forfiltration isan eficienttechnique for removing white blood cels from blood products.In China，theclinical applicationof leukocytedepletion technologybasedon LDFis not yet widespread.To provide scientific guidance fortherationaluseof leukocyte一depleted bloodin China，basedon systematic literature retrieval and evidence一based medicine methods，the Delphi expert consensus method was employed to form expert recommendations regarding the applicable population，personnel qualifications and environmental facilities，timing of use，qualitycontrol，and managementofLDFleukocyte depletion.It is pointedout that medical institutions should selectivelyimplement leukocyte depletion technology for certain target populations based on localeconomic levels，blood transfusion service capabilities，and the disease spectrum of service recipients.Regions or medical institutions with high economic levels and strong blood transfusion service capabilities areencouraged to widely implement leukocyte depletion technology.Thisconsensus canprovide guidane and reference for the clinical applicationofleukocyte depletion technology in blood transfusion therapy， ensuring the safety of clinical blood use.

Key words Leukocyte Depletion Technology ; Blood Transfusion Therapy; Blood Quality; Blood Safety; Expert Consen sus

First-author'saddress Shanghai Sixth People's Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai，200233，China

血液制劑的非治療性白細(xì)胞同如非溶血性發(fā)熱性輸血反應(yīng)（Febriletions，F(xiàn)NHTR）、血小板輸注無效種異體輸注會引起一系列副作用，Non一Hemolytic Transfusion Reac-（Platelet Transfusion Refractoriness，PTR）、輸血相關(guān)移植抗宿主?。═ransfusion Related Graft-Versus一HostDisease，TA-GVHD）、輸血相關(guān)急性肺損傷（TransfusionRelat-edAcuteLungInjury，TRALI）、白細(xì)胞相關(guān)感染性疾病等。（剩余18428字）