單質(zhì)硫催化查爾酮類化合物選擇性還原制備二氫查爾酮的研究
打開文本圖片集
[中圖分類號]R284.3 [文獻標(biāo)志碼]A [文章編號]doi：10.3969/j.issn.1674-070X.2025.04.011
[Abstract]Objective To investigate thesynthetic method for preparing dihydrochalcones byselectivelyreducing chalcones using water asthehydrogensourceunderthecatalysisof elemental sulfur.Methods Chalcone wasusedasa model substrateto investigatetheoptialreactionconditions，andthinfluenceofdfrenttypesofsubstituentsonthereactionyieldwasexamined. Results Theoptialreactionconditionwereasfolows：0.5mmolofchalcone，1.25equivalentsofelementalsulfur，2.5quivalents of 1，4-diazabicyclo [2.2.2]octane， 400μL of water，and 2.5 mL of N，N-dimethylformamide，with the reaction conducted at 120°C for 12hunderN2protectionAseriesofdihydrochalcones wereefectivelyobtainedintheexpansionofthesubstratescope，andtheir structures were confirmed by 1H -NMR， 13C -NMR， and HR-ESI-MS. Conclusion The system of elemental sulfur/water/l， 4- （204號 diazabicyclo2ctane/N，dimetyforaideanselecivelyducechaonetodrohalcone.Thsmethdfaturawide range of applicable substrates， environmental friendliness， simple operation， and excellent yield.
[Keywords] elemental sulfur; chalcone;dihydrochalcone; selective reduction; synthesis
二氫查爾酮類化合物屬于查爾酮家族的主要成員，含有1，3-二苯基丙酮基本骨架。（剩余11295字）