衰老驅(qū)動代謝相關(guān)脂肪性肝病的機(jī)制及靶向治療策略研究進(jìn)展

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Abstract：Metabolicassociatedfaty liverdisease（MAFLD）isaliverdiseaseasociated withmetabolicdisorders，and itis characterizedbyexcesivefatdepositioninhepatoctesandiscloselyasociatedwithinsulinresistanceandgeneticsuscetibility. Aging isanimportantfactorintheprogressionof MAFLDandispositivelycorrelatedwiththemortalityrateof patients with MAFLD.The pathophysiological mechanismsofMAFLDinvolve lipid metabolismdisorders，nsulinresistance，inflammation，and oxidativestress，andaging exacerbates thepathological processofMAFLDbyfurtheraffecting these keymechanisms.Cell senescence isanimportantfactorinorganismalaging，ndtherapeuticstrategies targetingsenescentcelscanrducetheumberof senescentcelsorinhibittheiflammatoryfactorsseretedbysuchcells，therebyhelping toslowdowntheprogressionofMAFL. Inaddition，thescreeningofnovelregulatoryfactorsprovidesnewtargetsforthedevelopmentofnewdrugsforMAFLDtreatment. Althoughseveralantiagingterapieshaveenteredclinicaltrials，furtherstudiesareneededtovalidatethespecificityandpotetial liverdamageof these therapiesduetothecomplex mechanismsof agingonthe liver.Transforming multisystemmetabolic dysfunction therapies for MAFLD into specialized therapies for aging may provide new ideas for MAFLDdrug development.

Key words：Non-alcoholic Fatt Liver Disease；Celular Senescence；Aging；Lipid Metabolism Disorders；Insulin Resistance Inflammation

非酒精性脂肪性肝病是一種以除外酒精和其他明確的損肝因素所致的以肝細(xì)胞內(nèi)脂肪過度沉積為主要特征的臨床病理綜合征，近期國際共識將其更名為代謝相關(guān)脂肪性肝?。╩etabolicassociated fatty liver disease，

MAFLD），更關(guān)注脂肪肝與代謝之間的雙向作用。（剩余18518字）