超聲內(nèi)鏡下選擇性食管胃靜脈曲張來源支穿刺組織膠封閉術(shù)與傳統(tǒng)內(nèi)鏡治療的隨機對照研究
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Abstract：ObjectiveToinvestigatethesafetyand eficacyof puncturecyanoacrylateselectiveseal（PCSS）underendoscopic ultrasound inthetreatmentofgastroesophageal varices（GOV）.MethodsAtotalof10patientswith livercirrhosiswho underwentendoscopictherapyforthesecondarypreventionofGOVbleeding inBeijingDitan Hospital，，CapitalMedicalUniversity， from March1to December31，2023 were enroledandrandomlydivided intoPCSS groupandtraditional endoscopygroup.The patients werefolowedupfor6monthsaftersurgery，andthetwogroups werecomparedintermsofclinical outcomeand complications.The primaryoutcome measure wastherateof allviationordisappearanceofGOV，and thesecondaryoutcome measure was variceal rebleeding and death.The independent-samples t test was used for comparison of normally distributed or aproximatelynormall distributedquantitativedatabetweentwogoups，and the Wilcoxon non-parametric test wasused for comparisonofnon-normalldistributedquantitativedatabetweentwogroups；thechi-squaretestortheFisher’sexacttestwasused forcomparisonof qualitative data between two groups.ResultsThere were 50 patients inthe PCSS group，among whomlpatient waslosttofollow-up，andtherewere5Opatients inthetaditionalendoscopygoup，mong whom3patients werelosttofollow-up. There werenosignificantdiferencesbetweenthetwo groups inbaselinedatasuchasage，sex，Child-Pughclass，varices grade， and GOV typing（all P>0.05 ）.Compared with the traditional endoscopy group，the PCSS group had significantly better results of the number of endoscopic treatment sessions （ t=-15.671 ， P =0.001），the total amount of tissue adhesive used（ t=-2.830 ， P= 0.006），and the rate of alleviation or eradication ofvarices sclerosis（ χ2 =7.078， P =0.029）.Both groups had low rates of postoperativerebleeding，adversereactions，andcomplications，andtherewerensignificant diferences between the two groups （all P>0.05 ）.ConclusionCompared with traditional endoscopy，PCSS can significantly enhance treatment outcome while maintaining safety standards.
Key Words：Esophageal and Gastric Varices；Echoendoscope；Embolization，Therapeutic； Treatment Outcome
Research funding：Beijing Municipal Administration of Hospitals Incubating Program（PX2023065）
食管胃靜脈曲張（gastroesophageal varices，GOV）破裂出血是肝硬化致死性并發(fā)癥[1]。（剩余10936字）