新技術在慢加急性肝衰竭全病程管理中的轉(zhuǎn)化與落地
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通信作者：，haili_17@126.com（ORCID：0000-0003-4174-9758）
Translation and implementation of new technologies in the whole-course management of acute-on-chronic liver failure
HEKai，LIHai
DepartmentofGastroenterology，hanghaiIstituteofDigestiveDisease，RenjiHospitalhanghi JiaoTongUniversityhoolo Medicine，Shanghai200001，China
Correspondingauthor：LI Hai，haili_17@126.com（ORCID：0000-0003-4174-9758）
Abstract：Acute-on-chronicliverfailue（ACLF）isaformofacutehepaticinsuficiencythatoccursinthecontextofachronic liverdisease，witharelativelyhighmortalityrate.ToimprovetheprognosisofACLFpatints，itissentialtoarlyidentifythe patients withpre-ACLFandconstantlyoptimizeandinovatetreatmentregimensforthediseaseintheprogresivestage.Wih more than10yearsofresearch，the Chinese CLIFconsortiumhasdevelopedanearlywarning modelforACLFand establishedasystem fortransferinghigh-riskpatients totertiaryhospitals.Atpresent，thereal-worldstudyhasalsoconfimedtheconsistencybetwen theearlywarningmodelandactualconditions inclinical practice，makingcontributions totheearlysreening，diagnosis，and treatmentofACLF.ThetreatmentoptionsfortheprogressivestageofACLFarealsoexpanding，fromthedevelopmentofiovative pharmaceuticalstotheuseofartificialliversupportandstemcelltherapy，andsuchtreatment modalities have madesignificant achievementsinclinicalstudiesandareexpectedtobeimplementedinthenearfuture.Thedevelopmentofamoreeicient diagnosticsystemandnovel treatmentmodalitieshasled toasignificantimprovementinthediagnosisandtreatmentofCLF.
KeyWords：Acute-On-Chronic Liver Failure；Early Diagnosis；Therapeutics；Prognosis
1慢加急性肝衰竭（ACLF）全病程的兩階段特征
ACLF作為肝衰竭中的主要類型，具有短期病死率高和病情發(fā)展迅猛的特點[1]。（剩余12233字）