機器人胰腺實質保留手術與腹腔鏡胰腺實質保留手術治療胰腺神經內分泌腫瘤的效果比較

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Abstract：ObjetiveTcompareandanalyetheclinicalappicationofrobot-asistedparechymal-sparingpancreatectomy（R-PSP） andlaparoscopicparenchymal-sparingpancreatectomy（L-PSP）inthe reatmentofpancreaticneuroendocinenoplasm（pNE）and to evaluatethesafetyandefcacyof theR-PSPprocedure.MethodsAretrospectiveanalysiswasperfoedfortheclinicaldataofpEN patientswhoundewentparencalsparingpancreatectomyinDepatmentofGeneralSrgery，eking UnionMedicalColeHospial， Peking Union MedicalColege，ChineseAcademyofMedicalSciences，fromDecember2017toAugust2023，andaccording tothe minimallyinvasivesurgicalprocedure，theyweredividedintoR-PSPgroupandL-PSPgroup.R-PSPandL-SPwerecomparedintesof theeffcacyofminimallyinvasiveprocedure，theoutcomeofpostoperativecomplications，andoncologicalficacyTheindepedentsamples t test or the Mann-Whitney U test was used for comparison of continuous data between two groups ; the chi-square test or the Fisher's exact test was used for comparison of categorical data between two groups；the Mann-Whitney U test was used for comparison of ranked data betweentwogroups.RsultsAtotalof45pNENpatientswereincluded，with9intheR-PSPgroupand36intheL-PSPgroup，andtere were no significant differences in baseline data between the two groups（all P>0.05 ）.There were no significant differences between the twogroupsinefationtropativbloodloss，traopativebodassiondteateofoesiotoaoto （all P>0.05 ）.Compared with the L-PSP group，the R-PSP group hada significantly longer length of postoperative hospital stay [10.00（9.00—15.00） days vs 7.50（ 6.00-10.00） days， Z=-2.356 ，P=0.017]and significantly higher hospital costs [86 610.44 （81 905.39—114 401.24） yuan vs 38 781.20 （31 708.39—50 514.76） yuan， Z=-4.001， P<0.001 ].There were no significant differences between the two groups in the incidence rates of serious postoperative complications（Clavien-Dindo grade ?II ），clinically relevant pancreatic fistula，delayed gastric emptying，and intra-abdominal infection（all P>0.05 ）. The postoperative 90-day mortality rate was 0% for both groups.ConclusionR-PSP has acceptable safety and efcacyin pNEN patients in clinical practice.

Key Words： Pancreatic Neuroendocrine Neoplasm；Robotic Surgical Procedures； Laparoscopy；Treatment Outcome

Researchfunding：NationalNaturalScienceFoundationofChina（82272917）；National HighLevelHospitalClinical Research Funding（2022-PUMCH-B-004）

胰腺神經內分泌腫瘤（pancreatic neuroendocrine neoplasm，pNEN）是一類起源于肽能神經元和神經內分泌細胞的罕見腫瘤，在分化程度、生物學行為上具有高度異質性。（剩余11426字）