基于冠狀動(dòng)脈造影的影像組學(xué)列線圖在預(yù)測(cè)擇期冠脈介入無(wú)復(fù)流中的應(yīng)用研究

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[中圖分類號(hào)]R541.4 [文獻(xiàn)標(biāo)志碼]A [文章編號(hào)] 1674-7887（2025）04-0332-06

Application studyofcoronaryangiography-based radiomicsnomogramin predicting no-reflow phenomenon during elective PCI*

XUPeishu，2*#，，YAOLihong*，LIU Hu，CAO Xinnan2，CHENYufeng2，ZHUO Jian’，F(xiàn)ANMengkang1，，SHENGHongzhuan*** （DepartmentofCardiology，Afiliated Hospitalof Nantong University，Jiangsu 226OO1; Medical Schoolof Nantong University）

[Abstract]Objective：Developmentofacoronaryangiography-basedradiomics nomogramforpredicting intraproceduralnoreflowriskduring electivepercutaneouscoronaryintervention（PCI）.Methods：Thisretrospectivestudyenrolled88patients undergoingelectivePCIandomlyalocatedintoatrainingset（62cases）andvalidationset26cases）.Radiomicsfeatures etracted frompreproceduralangiographicimageswereanalyzed throughunivariatescreeningandLASSOregresiontoidentifykey predictors.Theseselectedfeatureswereintegratedwiththeindependentclinicalrisk factortoconstructthenomogrammodel. Model performancewassystematicallyevaluatedusing ROC curveanalysis，F(xiàn)1-score，and decisioncurve analysis（DCA）. Results：Theradiomicsnomogram demonstratedsuperior predictiveperformance，with AUCof O.897（O.816-0.978）in the trainingsetand0.810（0.64-0.979）inthevalidationset，ouperforingboththeclinical-onlymodel（0.77.696andadioics only model（0.792-0744）.ItalsoachievedahigherF1-score（0696）comparedwiththeclinical-onlymodel0.692）andradiic onlymodel（0.545）.DCAfurthervalidateditsclinicalutility.Conclusions：Theradiomics-basednomogramderivedfrom coronaryangiographydemonstratessuperiorpredictiveperformance comparedwithclinical-onlyandradiomics-onlymodels， enabling more effective risk stratification of no-reflow during elective PCI.

[Key words] acute coronary syndrome; no-reflow;percutaneous coronary intervention; radiomics

經(jīng)皮冠狀動(dòng)脈介人治療（percutaneouscoronaryintervention，PCI）已經(jīng)成為處理冠狀動(dòng)脈粥樣硬化性心臟病（以下簡(jiǎn)稱冠心?。┑闹匾委熓侄沃?。（剩余7721字）