卡培他濱維持治療在晚期三陰性乳腺癌中的生存獲益分析
打開文本圖片集
DOI：10.16424/j.cnki.cn32-1807/r.2025.04.004
[關(guān)鍵詞]晚期乳腺癌；卡培他濱；腫瘤標(biāo)志物；炎癥反應(yīng)；免疫功能 [中圖分類號]R737.9 [文獻(xiàn)標(biāo)志碼]A [文章編號] 1674-7887（2025）04-0327-05
Survival benefitanalysisof capecitabinemaintenance therapyin advanced triple-negative breast cancer*
XUTonglin**，SHAO Qi2*** （204 （Departmentof Thyroid and Breast Surgery，Affiliated NantongHospital 3of Nantong University，Jiangsu 226OO6; 2Department of Chemotherapy，Afiliated Hospital of Nantong University）
[Abstract]Objective：Toinvestigate thesurvival benefitsofcapecitabinemaintenance therapyinadvancd triple-negative breastcancer.Methods：Seventycasesof advanced triple-negativebreastcancerinAfiliated Hospitalof Nantong University fromJanuary2020toJanuary2O22 werecollctedanddividedintocontrolgroup（TXchemotherapyregimen）andobservation group（TXchemotherapyregimen+capecitabinemaintenance therapy）accrding todiferenttreatmentregiments.Theclinical efcacyof thetwogroupswascompared，andthelevelsofserumtumormarkers，inflammatoryesponseindicators，mmune function indicators，adversereactionsandsurvivalafter24monthsoffollow-upweredetected.Results：Theefectofobservation group was better than that of control group（ P <0.05）.After treatment， the levels of tumor markers and inflammatory factors were decreased inboth groupscompared with before treatment，andthelevels werelower inobservation group（P 0.05）.After 24 months of follow-up，the survival was 22 cases（62.86 % ） in the observation group and 12 cases（34.29 % ） in the control group，and the difference in 24- month survival rate between the two groups was statistically significant（Log-rank χ2 =6.555， P<0.05 ）.Conclusion： Capecitabine maintenance therapycannotonlyeffctivelyreduce the levelof serum tumor markersandbutalso improve inflammatory response，theimmune functionand prognosisof patientswithadvanced triple-negative breastcancer，and hasacertainsafety. [Key Words]advanced breast cancer; capecitabine; tumor markers; inflammatory response; immune function
乳腺癌作為女性常見惡性腫瘤，其臨床通常表現(xiàn)為乳房腫塊、皮膚改變、乳頭回縮、溢液等癥狀。（剩余8421字）