腦白質高信號與主觀認知下降相關性的研究進展

中圖分類號：R749.1 文獻標識碼：A 文章編號：1000-503X（2025）01-0110-08

DOI：10.3881/j.issn.1000-503X.15966

Advances in the Correlation Between White Matter Hyperintensity and Subjective Cognitive Decline

ZHANG Jingshi，LIU Guoyun，SHI Anqi，YANG Zeqiu，Mamuke ? Yerebake，WANG Jun，YAN Chaoqun

DepartmentofAcupunctureandMoxibustion，Dongzhimen Hospital，Beijing UniversityofChinese Medicine，BeijingOO7o，China

Corresponding author：YAN Chaoqun Tel：O10-84013147，E-mail：yanchaoqun857@126.com

ABSTRACT： As the population is aging rapidly，the incidence of Alzheimer's disease （AD） is increasing year byyear. The World Health Organization stresss that early prevention plays a keyrole in reducing the incidenceof AD.Subjective cognitive decline （SCD）is an early window of AD development，and timely intervention can efectivelyslow downthe progression of the disease or prevent it from developing into dementia，thus reducing the burden on the society.White matter hyperintensity（WMH） can effectivelyreflect white matter changes and provide strong evidence to identify SCD.In this paper，we review the recent research progress in WMH and SCD，reveal the problems in the current research on WMH，explain the correlation between WMH and SCD in terms of physiopathology and cognitive function，and put forward several suggestions for the future research.

Key words：subjective cognitive decline；white matter hyperintensity；Alzheimer’s disease

ActaAcadMedSin，2025，47（1）：110-117

阿爾茨海默?。ˋlzheimer’sdisease，AD）是一種進行性大腦疾病，它損害記憶、思維和決策能力，具有高患病率、高致殘率和高致死率的“三高”特點[1-2]，造成嚴重的社會負擔。（剩余23786字）