帕博利珠單抗致免疫性心肌炎1例報(bào)告及文獻(xiàn)回顧分析

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摘 要 1例老年女性黑色素瘤患者接受帕博利珠單抗200 mg治療，21 d后發(fā)生免疫性心肌炎伴橫紋肌溶解，考慮與帕博利珠單抗治療有關(guān)。經(jīng)給予糖皮質(zhì)激素沖擊治療和對(duì)癥支持治療，患者病情逐漸好轉(zhuǎn)并出院。

關(guān)鍵詞 帕博利珠單抗 免疫性心肌炎 免疫檢查點(diǎn)抑制劑

中圖分類(lèi)號(hào)：R979.19； R542.21 文獻(xiàn)標(biāo)志碼：B 文章編號(hào)：1006-1533（2022）17-0011-05

引用本文 李娟， 賈婉， 邱央， 等. 帕博利珠單抗致免疫性心肌炎1例報(bào)告及文獻(xiàn)回顧分析[J]. 上海醫(yī)藥， 2022， 43（17）： 11-15.

A case report and literature review of immune myocarditis induced by pembrolizumab

LI Juan1， JIA Wan2， QIU Yang3， XI Wenqi4（1. Department of Pharmacy， Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China； 2. Department of Pharmacy， Wuxi Branch of Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Wuxi 214000， China； 3. Department of Pharmacy， Guhua Hospital of Fengxian District， Shanghai 201499， China； 4. Department of Oncology， Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China）

ABSTRACT An elderly female melanoma patient who received 200 mg of pembrolizumab developed immune myocarditis with rhabdomyolysis 21 days later， which was considered to be related to pembrolizumab treatment. The patient was given glucocorticoid pulse therapy and symptomatic treatment， her condition was gradually improved after treatment and was finally discharged from the hospital.

KEy WORDS pembrolizumab； immune myocarditis； immune checkpoint inhibitors

黑色素瘤是一種來(lái)源于黑色素細(xì)胞的惡性腫瘤，多發(fā)生于皮膚，也可見(jiàn)于黏膜和內(nèi)臟，其約占全部腫瘤的3%。（剩余9614字）