表觀生物年齡加速預(yù)測(cè)老年重度冠狀動(dòng)脈鈣化患者行冠狀動(dòng)脈旋磨術(shù)后主要不良心血管事件的研究

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Association Between Epigenetic Age Acceleration and Major Adverse Cardiovascular Events in Elderly Patients with Severe Coronary Artery Calcification After Rotational Atherectomy

LIRuiting，MAYue，MA Rui，ZHANGRongxiu，LIUZhanwen

（Cardiovascular Medicine Department，The Third People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi

830000， Xinjiang ，China）

【Abstract】ObectiveToinvestigatethrelationshipbetweenepigeneticgeacceleration（EAA）ndtheoccurnceofmajoradverse cardiovascularevents（MACE）afterrotationalatherectomy（RA）inelderlypatientswithseverecoronaryarterycalcification（CAC）.

MethodsAretrospetivestudywasconductedonatotalof2O6elderlypatientswithsevereCACwhounderwentRAatTheThirdPeople's Hospital of Xinjiang Uygur Autonomous Region from July2O13 toAugust 2O23.The patients werecategorized into EAA + group（PhenoAge> actualage）andEAA-group（PhenoAge （204 0.619）.TheAUCvaluesfortheROCcurveat1，3，5，and8yearswereO.72，.76，0.78，andO.75，respectivelyDCAresulslso demonstratedthegoodpredictivevalueofEAAforMACE，whilethecalibrationcurveindicatedahighmodelacuracy.Thenomogram visualized heriskofACEourrenceinpatients.ConclusionThereisarelatioshipbetweenEAAandtheocurenceofMCEafterRA inelderlypatintswithsevereCAC，whichcan helphealthcare providers identify high-riskpatientsandimprovepatientoutcomes.

【Keywords】Epigeneticageaceleration；Coronaryarterycalefication；Elderlypatient；Rotationalatherectomy；Majoradverse cardiovascular events

冠狀動(dòng)脈鈣化（coronaryarterycalcification，CAC）是指冠狀動(dòng)脈血管壁內(nèi)出現(xiàn)鈣質(zhì)沉積的現(xiàn)象，是動(dòng)脈粥樣硬化的一種表現(xiàn)。（剩余7849字）