艾司洛爾 + 體外膜肺氧合治療重癥膿毒癥的臨床療效分析

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Clinical analysis of esmolol combined with extracorporeal membrane oxygenation in the treatment of severe sepsisChen Bowen，Wu Jinhai，Zhao Juxin，Sun Hang，Liu Dong.Nanyang Key Laboratory of Sepsis Transformation，Henan UniversityAffiliatedNanyangFirstPeople'sHospital，Henan4730oo，China

【Abstract】ObjectiveTo investigate the clinical effcacy of esmolol combined with extracorporeal membrane oxygenation （ECMO）in the treatment of adult refractory septic shock with respiratory failure.Methods Inthis study，1OO patients withrefractory septic shock with respiratory failure inour hospital were randomly divided into an observation group （n=50）andacontrol group （n=50）.Thecontrol group receivedECMO treatment， while the observation group received esmololon thebasisof ECMO treatment.Inthe course of the study，the vital signs，inflammatoryreaction indexandorgan function index of the two groupswererecordedin detail，and the prognostic indexes such as sequential organ failure score，incidence of adverse events and succesful weaning recovery rate were compared between the two groups.ResultsAfter treatment，compared with the control group， the patients in theobservation group hadsignificantlylower heartrate，cardiac output，higher meanarterial pressure （MAP），lower C-reactiveprotein，white bloodcell count，procalcitonin，higherarterialoxygen content， higheroxygenation index and lower respiratory index，andlower acutephysiology，chronic health scoreI and sequential organ failure score.The incidence of adverse events was lower（ P <0.05）.ConclusionEsmolol combined with ECMO hasgood clinical eficacy in the treatment of severe sepsis，whichcan significantly improve the vitalsigns of patients，reduce inflammatory reactions，protect organ function，and have feweradverse events.

【Key words】 Sepsis;Adult;Respiratory insufftciency；Esmolol; Extracorporeal membrane oxygenation

重癥膿毒癥是一種由感染引起的全身性炎癥反應綜合征，病情嚴重且進展迅速，常導致多器官功能衰竭，從而導致膿毒癥休克。（剩余7460字）