帕金森病血清Hcy和25-（OH)D3與睡眠障礙的相關(guān)性分析

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Correlation Analysis of Serum Homocysteine（Hcy） and 25-Hydroxyvitamin D3 [25-（OH） D3] with Sleep Disordersin Parkinson'sDisease

YANG Meiqing，HUANG Ziying，XU Dandan （Quanzhou First Hospital，Quanzhou 362OOO，China）

AbstractObjective：Toinvestigatethediferencesinserumhomocysteine（Hcy）and25-hydroxyvitaminD325-（OH）D3] levelsiParkinson'sdisease（PD）patientsatdiferent Hoehn-Yahrstagesandanalyze theircorelation with sleep disorders.Methods：Atotalof96PDpatients with sleepdisorderswereselectedastheobservationgroupanddividedintomild （ n=30 ），moderate（ n=40 ），and severe（ n=26 ）groups based on Hoehn-Yahr classification. Additionally，4O PD patients without sleepdisorders wereselectedasthecontrol group.Theserum levelsofHcy，25-（OH）D3，andsleepstructureindiceswere comparedamongthegroups，andcorrelations wereanalyzed.Results：Comparedwiththecontrolgroup，theoservationgrouphad significantly higher serum Hcy levels and lower serum 25-（OH）D3 levels（ P<0.05 ）.Differences in serum Hcy，25-（OH） D3， sleep efficiency，seeplatencyEMlatency，nd wakefulnesindex weresignificantacrosstheild，oderate，andsveregous （ P<0.05 ）.Pearsoncorrelation analysis showed that serum Hcy was positively correlated with sleep latencyand wakefulness index，and negatively correlated with sleep efficiency and REM latency，with correlation coefficients （r） of 0. 783，0.821，-0.754， and-0.718，respectively.Serum25-（OH）D3wasnegativelycorelatedwithsleplatencyand wakefulnessindex，ndpositively correlated with sleep efficiency and REM latency，with correlation coefficients （r） of -0.842，-0.738，0.811，and 0.753，respectively.Conclusion：Therearesignificantdiferenesinserum Hcy，25-（OH）D3levels，andsleepstructure indicesamongPD patients at diferent Hoehn-Yahrstages.Serumbiomarkersarecloselycorelated with slepstructure indicesand mayserve asrapid indicators for assessing sleep disorders in PD patients.

KeywordsParkinson'sdisease；Hoehn-Yahr staging；Slep disorders；Homocysteine；25-Hydroxyvitamin D3；Correlation 中圖分類號(hào)：R443 文獻(xiàn)標(biāo)識(shí)碼：A doi：10.3969/j. issn.2095-7130.2025.02.002

帕金森?。≒arkinson'sDisease，PD）是一種神經(jīng)系統(tǒng)退行性疾病，多發(fā)生在中老年人群中，數(shù)據(jù)顯示，歐美地區(qū)60歲以上人群PD患病率達(dá)到 1% ，80歲以上人群PD患病率已超 4% ，而我國(guó)65歲以上人群PD患病率亦達(dá) 1.7% ，應(yīng)該引起重視。（剩余6253字）