酒精、咖啡、綠茶和乳制品的攝入量與前列腺癌的關(guān)聯(lián)：兩樣本孟德爾隨機化研究

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Associations of alcohol，coffee，green tea and dairy products with prostate cancer：a two，sample Mendelian randomization study

CHAI Hongqiang，SHAO Jinkai，WU Ming，ZHAO Kejie，PANG Lei

（Department of Urology，The Fifth Clinical Medical College of Shanxi Medical University，Shanxi Provincial Peoples Hospital，Taiyuan 030012，China）

ABSTRACT：ObjectiveA two，sample Mendelian randomization method was used to explore whether there is a causal relationship between the intake of alcohol，coffee，green tea and dairy products and the incidence of prostate cancer （PCa），in order to clarify the risk factors for the incidence of PCa and find a prevention pathway for PCa.MethodsData of alcohol，coffee，green tea，dairy products and prostate cancer were collected with genome，wide association study （GWAS）.The causal relationship between their intake and the risk of PCa was analyzed with two，sample Mendelian randomization （2SMR）.MR analysis was conducted with inverse，variance weighting （IVW）.Sensitivity analysis was performed with weighted median，MR，Egger regression，Mendelian randomization

pleiotropy residual sum and outlier （MR，PRESSO） tests.Results Coffee intake （OR：0.994，95%CI：0.990-0.999，P=0.014） and green tea intake （OR：0.999，95%CI：0.998-0.999， P=0036） were negatively correlated with the risk of PCa.Alcohol intake （OR：0.997，95%CI：0.990-1.004，P=0.392） and dairy intake （OR：1.025，95%CI：0.983-1.069，P=0.256） were not associated with the risk of PCa.In weighted median，MR，Egger regression，and retention one method analyses，the results were robust without heterogeneity or pleiotropy.

Conclusion There was a causal association between coffee intake and green tea intake and the onset of PCa，but no causal association between alcohol intake and dairy intake and PCa onset.

KEY WORDS：Mendelian randomization；prostate cancer；causal inference；genome，wide association study；alcohol；coffee；green tea；dairy products

摘要：目的采用兩樣本孟德爾隨機化方法探究酒精、咖啡、綠茶和乳制品的攝入量與前列腺癌（PCa）發(fā)病之間是否存在因果關(guān)系，以期幫助明確PCa的發(fā)病風(fēng)險因素，從而幫助尋求PCa的預(yù)防途徑。（剩余11463字）