胃腸間質(zhì)瘤并發(fā)胃腸道出血患者的生存狀況分析

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[中圖分類號]R574.63［文獻標志碼］A[文章編號]2097-5716（2025）03-0390-04

DOI： 10.13308/j.issn.2097-5716.2025.03.015

Analysis on survival status of patients with gastrointestinal stromal tumor complicated by gastrointestinalbleedingWU Fengjuan，LIU Na， ZHAO Ya’nan， CHEN Pei（Department of Gastroenterology， Zhengzhou FirstPeople's Hospital， Zhengzhou Henan 450004，China）

[Abstract]ObjectiveTo analyze the survival status of patients with gastrointestinal stromal tumor （GIST） complicated bygastrointestinal bleeding.MethodsThe medical record and postoperative folow-updata of 112 patients with GIST were collcted.All patients were treated with either endoscopic submucosal excavation or laparoscopic surgical intervention. They were divided into a bleeding group （ n=43 ） and a non-bleeding group （ n= 69）according to whetherthe patients were complicated by gastrointestinal bleeding.The pathological characteristics of the tumor，the prognosis of surgical treatment，and thesurvival status of the patients were observed in the two groups.ResultsThere were no statistically significant differences in sex or age between the two groups （both P> 0.05）.In the bleeding group，the proportion of patients with tumors locating outside the stomach was higher，the tumors were larger，therisk grade was higher，and the mitotic figures were more compared to those in the nonbleeding group （all P<0.01 ）. Postoperative immunohistochemical examination results showed that the positive rates of postoperative tissue CD34，CD117，smoth muscle actin，and DOG-1 in the bleeding group were all significantly higher than those in the non-bleeding group （all P<0.05 ）. The recurrence or metastatic rate，and mortality of the patients in the bleeding groupduring folow-up were also both significantly higher than those in the non-bleeding group （the recurrence or metastatic rate ： 37. 21% vs. 15. 94% ，the mortality： 18.60% Us. 4.35% ；both P<0.05 ）. ConclusionPatients with GIST comnlicatedhvoastrointestinal hleeding tend tn have tumorsnredominantlv

distributed inextragastric tissues，which demonstrate accelerated growth speed，higher malignant potential，andare also associated with significantly increased postoperative recurrence or metastasis rate，and mortality. [Key words]gastrointestinal stromal tumor；gastrointestinal bleeding；survival status ； immunohistochemistry

胃腸間質(zhì)瘤（gastrointestinal stromal tumor，GIST）是胃腸道較為少見的惡性腫瘤，在中老年人群中多發(fā)，來源于胃腸間質(zhì)的Cajal細胞或更加原始的干細胞[1-2]。（剩余4557字）