阻塞性睡眠呼吸暫停低通氣綜合征患者動態(tài)動脈硬化指數(shù)與脈壓、血壓變異性的關(guān)系

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[中圖分類號]R540.4;R563.9[文獻標志碼]A［文章編號]2097-5716（2025）03-0313-06

DOI： 10.13308/j.issn.2097-5716.2025.03.001

[引用格式] 王惠歆，吳毅程，宿燕崗.阻塞性睡眠呼吸暫停低通氣綜合征患者動態(tài)動脈硬化指數(shù)與脈壓、血壓變異性的關(guān)系[J]．實用心電與臨床診療，2025，34（3）：313-317.

Relationship between ambulatory arterial stifess index and pulse pressure or blood pressure variability in patients with obstructive sleep apnea hypopnea syndromeWANG Huixin'， WU Yicheng'， SU Yan'gang2 [1.Department of Electrocardiogram，Zhongshan Hospital，F(xiàn)udan University（Xiamen Branch），Xiamen Fujian 361015； 2. Department of Cardiology， Zhongshan Hospital， Fudan University， Shanghai 2OOO32， China] [Abstract]ObjectiveTo investigate the correlation between ambulatory arterial stiffness index （AASI）and pulse pressure or blood pressure variability （BPV） in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）.MethodsA total of 2O5 patients specificallydiagnosed with OSAHS were enrolled as research objects. They completed general data collection，and polysomnography and ambulatory blood pressure monitoring.Based on the clasfication of circadian blood pressure rhythm，the study population was divided intoa dipper blood pressure group （ n=92 ） and a non-dipper blood pressure group （ n=113 ）. We compared the general clinical characteristics between the two groups as wellas the correlation between AASI and ambulatory blood pressure parameters by using Pearson corelation analysis.Multiple linear regression analysis was applied to explore the relationship between AASI ad pulse pressure or BPV. ResultsThe AASI of the non-dipper blood pressre group was significantly higher than that of the dipper blood pressure group （ P<0.01 ）. AASI was positively correlated with age，24-hour mean systolic blood pressure and pulse pressure，while it was negatively correlated with 24-hour mean diastolic blood pressure，and the decline ratio of nocturnal systolic and diastolic blood pressure （all P<0.05 ）. Pulse pressure was associated with AASI if BPV remained constant （ P<0.05 ）. ConclusionThe AASI of OSAHS patients demonstrates an association with pulse pressure and age.AASI may serve as a promising indicator reflecting arterial stiffness .

[Key words]obstructive slee apnea hypopnea syndrome；ambulatory arterial stiffess index；blood pressure variability ；pulse pressure;arterial stiffness

阻塞性睡眠呼吸暫停低通氣綜合征（obstructivesleep apnea hypopnea syndrome，OSAHS）是睡眠過程中由多種原因引起上氣道部分或完全塌陷，從而引起機體發(fā)生一系列病理生理改變的臨床綜合征。（剩余8274字）