香豆素類化合物結(jié)構(gòu)修飾合成及抑菌活性測定
打開文本圖片集
摘 要：以取代水楊醛與丙二酸二乙酯為原料，合成中間體3-甲酸乙酯-香豆素衍生物后進行酯的堿性水解反應，酸化得到反應中間體3-甲酸-香豆素衍生物，在此基礎上使用羧酸?；呋瘎┐呋罨M行一系列?；〈玫侥繕嘶衔?6個，并測定目標化合物的抑菌活性。結(jié)果表明，部分目標化合物抑菌活性效果良好。
關鍵詞：香豆素；衍生物；合成；抑菌活性
中圖分類號：TQ225.2
文獻標志碼：A文章編號：1001-5922（2023）01-0113-04
Synthesis and antibacterial activity of coumarins
GAO Dongmei1，DU Zhenting2
（1.Yangling Vocational & Technical College，Yangling 712100，Shaanxi China ;
2.Northwest A&F University，Yangling 712100，Shaanxi China
）
Abstract： Using substituted salicylaldehyde and diethyl malonate as raw materials，the basic hydrolysis reaction of esters was carried out after the synthesis of ethyl 3-carboxylate-coumarin derivatives，and the reaction intermediate 3-carboxylic acid-coumarin derivative was obtained by acidification.On this basis， bean derivatives were catalyzed and activated by a carboxylic acid acylation catalyst，and a series of acylation substitutions were carried out to obtain 26 target compounds， and the antibacterial activities of the target compounds were determined.The results showed that some target compounds had good antibacterial activity.
Key words：coumarin;derivatives;synthesis;bacteriostatic activity
香豆素類化合物具有α-苯并吡喃酮結(jié)構(gòu)［1］，廣泛存存在于植物、動物、微生物及其次生代謝物中。（剩余7024字）