《骨質(zhì)疏松癥臨床治療生物制劑循證用藥指南》推薦意見外審：一項(xiàng)橫斷面調(diào)查

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中圖分類號(hào)R969.3 文獻(xiàn)標(biāo)志碼A 文章編號(hào) 1001-0408（2025）09-1025-05

DOI 10.6039/j.issn.1001-0408.2025.09.01

ABSTRACT OBJECTIVE To assess the scientific rigor， clarityandfeasibilityoftherecommendationsofthe GuidelinesforEvidence-basedUseofBiological Agentsforthe Clinical TreatmentofOsteoporosis（hereinafterreferredtoas theGuideline）through external review，in order to further revise andimprovetheGuidelinerecommendations. METHODS This study employed a cross-sectional survey research design，a convenience sampling method was adopted

toselectfrontlinemedicalworkersinthefieldfosteoporosis（includingclnicaldoctors，iicalpharmacistsandurses）aswel aspatientsortheirfamilymembers.Externalreviewwasconductedthroughacombinationofclosed-endedandopen-ended electronicquestionnairestogetfeedbackfromthemontheappreciation，clarityandfeasibilityofthe32preliminary recommendationsintheGuideline.RESULTSAtotalof90externalreviewsubjetsfrom15hospitalswerecollected，including45 clinicaldoctors，15clinicalpharmacists，15nursesand15patientsortheirfamilymembers.Theoverallappreciationdegreeof recommendations was 9 9 . 3 8 % ，the overall clarity degree of recommendationswas 9 8 . 9 2 % ，and the overall feasibility degree of recommendations was 9 9 . 6 5 % . At the same time，111 subjective suggestions were collected，which provided an important reference forthefurtherimprovementoftheGuidelinerecommendations.Basedontheabovefedback，theGuidelinesteeringcommiteeand coreexpert grouprevisedthewordingof12draftrecommendationswithout deletion，andfinallydetermined32recommendations. CONCLUSIONSTheexternalreviewprovidesanimportantbasis forthefinalformationof theGuideline，furtherimproves the scientificrigorlarityandfeasibityofthecommendations，ndesuresthestandardization，practicalityandimplementabilityof the Guideline.

KEYWORDSosteoporosis；biological agent；evidence-based medication guideline；external review；recommendations

臨床實(shí)踐指南是醫(yī)學(xué)領(lǐng)域的重要指導(dǎo)性文件，其基于當(dāng)前可獲得的最佳證據(jù)，為臨床提供科學(xué)、權(quán)威且規(guī)范的治療建議。（剩余7668字）