中藥調(diào)控NLRP3炎癥小體改善心肌纖維化的研究進展

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中圖分類號R965；R285 文獻標志碼A 文章編號 1001-0408（2025）08-1008-05

DOI 10.6039/j.issn.1001-0408.2025.08.21

Research progress on the improvement of myocardial fibrosis by traditional Chinese medicine through regulation of NLRP3 inflammasome

ZHANG Rui'，YAN Jingshun'，JIA Fuyun'，JIA Kexin'，LIU Chenyang'，LIU ，LI ，XU Qiang2（1. Graduate SchoolTianjin University of Traditional Chinese Medicine， Tianjin 3016l7， China；2.Dept.of Cardiology，the Second Afiliated Hospital of Tianjin University of Traditional Chinese Medicine， Tianjin 300150， China）

ABSTRACTMyocardialfibrosis（MF），characterizedbydecreased cardiacfunction and myocardial compliance，isa pathologicalprocessandaprogressionfactorinvariouscardiovasculardiseasesThenucleotide-bindingdomainleucine-richrepeat and pyrindomain-containingreceptor 3（NLRP3）inflammasome iscloselyrelated tothedevelopmentof MF.Recent studies have shownthattraditionalChinesemedicine（TCM）canregulatetheNRPinflammasometoaleviateMFBasedonthisthisarticle systematicallysummarizestheresearchprogressonthemechanismsbywhichTCMregulatestheNLRP3inflammasometo improve MF.It is foundthatactiveingredientsof TCM，suchasalkaloids（lycorine，vincristine，bufalin），saponins（astragaloside IV， diosgenin， ginsenoside ），terpenoids（celastrol，oridonin），and phenols（polydatin，curcumin，phloridzin） as well as TCM formulas（Zhachong shisanwei pillZhilong huoxuetongyucapsules，Luqiformula）caninhibit theactivationof the NLRP3 inflammasome， thereby suppressing the release of inflammatory factors such as interleukin- 1β and IL-18， reducing inflammatory damagetomyocardiatissuealeviatingexcessivedepositionoftheextracellulaatrixandthusexertingtheeecofiproving MF.

KEYWORDSactivecomponentof TCM；TCMformula； myocardialfibrosis；NLRP3inflammasome；mechanismof action

心肌纖維化（myocardialfibrosis，MF）是由中、重度冠狀動脈粥樣硬化性狹窄引起心肌纖維持續(xù)性和（或）反復加重的缺血缺氧所導致的心肌纖維組織增生。（剩余12705字）