中藥調(diào)控抑郁癥相關(guān)信號通路研究進(jìn)展
【摘要】文章簡述了中藥調(diào)控cAMP、MAPK、BDNF、PI3K/Akt等信號通路在治療抑郁癥中的實(shí)驗(yàn)研究進(jìn)展。分析表明這些信號通路主要通過抑制神經(jīng)炎癥、抗氧化應(yīng)激、調(diào)控神經(jīng)細(xì)胞凋亡、促進(jìn)神經(jīng)因子表達(dá)及促進(jìn)神經(jīng)元修復(fù)等以達(dá)到抗抑郁效果。以期為中醫(yī)藥治療抑郁癥提供依據(jù)。
【關(guān)鍵詞】抑郁癥；信號通路；中藥；研究進(jìn)展
【中圖分類號】R749.7+9
【文獻(xiàn)標(biāo)志碼】 A【文章編號】1007-8517（2024）18-0049-05
DOI：10.3969/j.issn.1007-8517.2024.18.zgmzmjyyzz202418011
Abstract：Its treatment is based on the hypothesis of hypothalamus pituitary adrenal axis imbalance，neuroplasticity hypothesis，monoamine neurotransmitter and other hypotheses.At present，western medicine has the shortcomings of short clinical validity and different adverse reactions.Therefore，the author of this article will summarize the specific roles of traditional Chinese medicine in the treatment of depression，in order to provide a basis for the treatment of depression with traditional Chinese medicine.
Keywords：Depression；Signaling Pathway；Traditional Chinese Medicine；Research Progress
抑郁癥是以抑郁情緒、失去快感為主要特征，伴情緒焦慮、疲倦、記憶力減退、睡眠障礙、無價(jià)值感或內(nèi)疚感、自殺意念為表現(xiàn)的一種慢性精神障礙［1］。（剩余10782字）