同軸靜電紡絲聯(lián)合富血小板血漿敷料在慢性創(chuàng)面治療中的應(yīng)用前景

［摘要］富血小板血漿可促進(jìn)慢性創(chuàng)面的愈合，但在臨床應(yīng)用過(guò)程中，傳統(tǒng)的給藥方式難以達(dá)到穩(wěn)定持續(xù)的有效治療濃度，治療效果并不確定。本文對(duì)同軸靜電紡絲聯(lián)合富血小板血漿的相關(guān)研究進(jìn)行綜述，對(duì)同軸靜電紡絲聯(lián)合富血小板血漿的新型生物敷料治療慢性創(chuàng)面的應(yīng)用前景進(jìn)行展望，以期為創(chuàng)面治療提供新的思路。

［關(guān)鍵詞］富血小板血漿；同軸靜電紡絲；生物敷料；傷口愈合；綜述

［中圖分類號(hào)］R318［文獻(xiàn)標(biāo)志碼］A［文章編號(hào)］2096-5532（2024）03-0467-03

doi：10.11712/jms.2096-5532.2024.60.108［開(kāi)放科學(xué)（資源服務(wù)）標(biāo)識(shí)碼（OSID）］

［網(wǎng)絡(luò)出版］https：//link.cnki.net/urlid/37.1517.R.20240730.1613.007;2024-07-3111：42：55

Application prospect of coaxial electrospinning combined with platelet-rich plasma dressing in the treatment of chronic woundSHAO Zhaoyin， ZHOU Ziyi， LENG Xiangfeng（Department of Burn and Plastic Surgery， The Affiliated Hospital of Qingdao University， Qingdao 266003， China）

［Abstract］Platelet-rich plasma can promote the healing of chronic wound， but in clinical application， the traditional administration method cannot achieve a stable and continuous effective treatment concentration， leading to an uncertain treatment outcome. This article reviews the research on coaxial electrospinning combined with platelet-rich plasma and explores the application prospect of the new biological dressing of coaxial electrospinning combined with platelet-rich plasma in the treatment of chronic wound， in order to provide new ideas for wound treatment.

［Key words］platelet-rich plasma; coaxial electrospinning; wound healing; biological dressings; review

創(chuàng)面愈合的過(guò)程包括止血、炎癥、增殖以及組織重塑[1-2]，影響這一修復(fù)過(guò)程的因素眾多，包括：內(nèi)源性因素，如細(xì)胞、細(xì)胞因子、趨化因子、炎癥因子、生長(zhǎng)因子等；外源性因素，如營(yíng)養(yǎng)狀況、基礎(chǔ)疾病、感染等。（剩余8370字）