豬顆粒細胞在卵泡閉鎖中的作用機制研究進展

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中圖分類號：S828.3 文獻標志碼：A 文章編號：0366-6964（2025）06-2537-09

Research Progress on the Mechanism of Porcine Granulosa Cells in Follicular Atresia

ZHAO Shunran，F(xiàn)U Guixin，PANG Zhaoqi，XIA Wei，LI Junjie，TAO Chenyu*College of Animal Science and Technology， Hebei Agricultural University， Baoding O71ooo， China）

Abstract： Despite the significant advancements in China’s animal husbandry sector， enhancing the reproductive capacity of livestock and poultry still remains a relentless pursuit for breeding farms.Follicular atresia，which refers to the non-ovulatory follicles，is extremely common in livestock and poultry and has become a significant factor constraining their reproductive capabilities，thus attracting increasing attention. Granulosa cells， as a key factor affecting follicular atresia，play a crucial role in the process of folicular atresia. Currently，most research findings indicate that the proliferation of granulosa cells can influence the development of follicles，while apoptosis of granulosa cels can lead to follicular atresia. However， the underlying mechanisms still require further exploration. This paper discusses the roles of granulosa cells in apoptosis，autophagy，ferroptosis， pyroptosis， and necroptosis， providing new perspectives and insights into the complex mechanisms of follicular atresia.

Keywords： pig; granulosa cells; follicular atresia; apoptosis; autophagy; non-coding RNA ? Corresponding author： TAO Chenyu，E-mail ： taochenyuty@163.com

卵泡閉鎖是指沒有達到優(yōu)勢卵泡并無法排卵的卵泡，閉鎖卵泡中卵母細胞逐漸退化，顆粒細胞與卵母細胞慢慢地變成纖維體被卵巢吸收[1]。（剩余19961字）