低級別嗜酸性腎腫瘤3例報告并文獻復習

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Low-grade oncocytic renal tumor：a report of 3 cases and literature review

SUN Xinguang SONG Zhixue GAO Shuangyou WEN Yingwu DENG Shaohui HAO Yichang LU Min ZHANG Shudong

（1.Department of Urology，Kailuan General Hospital，Tangshan 063000； 2.Department of Urology，Peking University Third Hospital，Beijing 100191，China）ABSTRACT：ObjectiveTo review the clinical information，imaging features，pathological manifestations and prognosis of low-grade oncocytic tumor （LOT），so as to improve the clinical understanding of the disease.MethodsThe imaging，clinicopathological and postoperative follow-up data of 3 LOT cases treated in Peking University Third Hospital during Feb.2020 and Sep.2022 were retrospectively collected.ResultsAll patients were male，aged 51—70 years.All tumors were single，with the maximum diameter of 14—21 mm. None of the patients had any specific clinical manifestations.The mass showed a circular isodense shadow on CT.All patients underwent nephron-sparing tumor resection.Postoperative pathology showed that the incision surface of the tumors was brownish-yellow or brown，and the tumors were solid or partially cystic.HE staining showed that the cells were uniformly eosinophilic；the nucleus was round or oval，with slight local perinuclear halo.Immunohistochemistry showed positive CK7 but negative CD117.Genetic testing in case 2 showed 1 potentially clinically significant somatic mutation TSC2.During the follow-up of 12-23 months，no recurrence occurred.ConclusionThere were no obvious clinical symptoms and imaging features of LOT，which morphologically showed heterozygous or borderline characteristics with renal eosinophilia and renal chromophobe cell carcinoma，and the biological behavior was indolent.Nephron-sparing tumor resection promised good prognosis.

KEY WORDS：low-grade；renal tumor；renal oncocytoma；chromophobe renal cell carcinoma摘要：目的總結(jié)3例低級別嗜酸性腎腫瘤（LOT）患者的臨床信息、影像學表現(xiàn)、病理表現(xiàn)及預后，提高臨床對該疾病的認識。（剩余8169字）