枸橡酸氫鉀鈉顆粒聯(lián)合微通道經(jīng)皮腎鏡碎石術(shù)治療老年腎結(jié)石的臨床研究

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Clinical Studyonthe Treatmentof ElderlyKidney StoneswithPotassium Sodium Citrate Granules Combined with Microchannel Percutaneous Nephrolithotomy/LUO Jie，SU Xiaokang，CHEN Kui，HU Yongwen.//Medical Innovation of China，2025，22（18）： 015-018

[Abstract]Objective：To investigate the efficacy of Potassium Sodium Citrate Granules combined with microchannel percutaneous nephrolithotomy （mPCNL） inthe treatment of elderly kidney stones.Method： A total of 102 elderly patients with kidney stones treated inSongzi People's Hospital from January 2O22to January 2024 were selected and randomly divided into acontrol group （mPCNL） and a study group （Potassium Sodium Citrate Granules combined with mPCNL），with 51 cases ineach group.The stone clearancerate，renal function，inflammatory factors， and stone recurrence rate were compared between the two groups.Result： One month after surgery，the stone clearance rate in the study group was higher than that in the control group （ P <0.05）; after a one-year follow-up，the recurrence rate in the study group was lower than that in the control group （P<0.05） .7 daysafter surgery，the levels of bloodureanitrogen（BUN），reatinie（Cr），cystatinC（CysC），interleukin-13（IL13），interleukin-6（IL-6）andCractive protein （CRP） in the study group were lower than those in the control group （ P<0.05 ）. Conclusion： The combination of Potassium Sodium Citrate Granules and mPCNL in the treatment of elderly kidney stones can improve stone clearance rate， reduce renal function damage，lower inflammatory factors and recurrence rate.

[KeyWords]Potassium Sodium Citrate GranulesMicrochannel percutaneous nephrolithotomyElderly sidney stonesRenal function

First-author'saddress： Department of Urology，Songzi People's Hospital，Songzi 434299，China doi：10.3969/j.issn.1674-4985.2025.18.004

腎結(jié)石是泌尿科常見病癥，其成因在于草酸、尿酸、胱氨酸等結(jié)晶物質(zhì)在腎臟內(nèi)部的不正常聚集，患者常表現(xiàn)出腰部或上腹部突發(fā)的劇烈疼痛，這種疼痛可能會向下腹部、腹股溝區(qū)域乃至會陰部放射[1]。（剩余5729字）